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Analysis of Erythrocyte Invasion Mechanisms ofPlasmodium falciparumClinical Isolates Across 3 Malaria-Endemic Areas in Ghana

2 Apr 2015

Abstract excerpt

BACKGROUND: Plasmodium falciparum invades human erythrocytes by using an array of ligands that interact with several receptors, including sialic acid (SA), complement receptor 1 (CR1), and basigin. We hypothesized that in malaria-endemic areas, parasites vary invasion pathways under immune pressure. Therefore, invasion mechanisms of clinical isolates collected from 3 zones of Ghana with different levels of...

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PMID: 25838264
DOI: 10.1093/infdis/jiv207

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