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Article

Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2009

Birmann Brenda M, Tamimi Rulla M, Giovannucci Edward, Rosner Bernard, Hunter David J, Kraft Peter, Mitsiades Constantine, Anderson Kenneth C, Colditz Graham A

Abstract excerpt

Insulin-like growth factor (IGF)-1 and interleukin (IL)-6 promote the proliferation and survival of multiple myeloma cells. Variation in genes related to IGF-1 and IL-6 signaling may influence susceptibility to multiple myeloma. To assess their etiologic role, we examined the association of 70 tagging single nucleotide polymorphisms (SNP) in seven IGF-1 and three IL-6 pathway genes with multiple myeloma risk in...

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Source

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Identifiers

PMID: 19124510
DOI: 10.1158/1055-9965.EPI-08-0778
PMCID: PMC2661109

Genes

IRS1
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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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