Article
Circulating levels of insulin-like growth factor I (IGF-I) and risk of multiple myeloma: An observational and Mendelian randomisation study.
British journal of haematology - 1 Jun 2026
Benavente Yolanda, Hermosa Sara, Papadimitriou Nikos, Clay-Gilmour Alyssa, Brown Elizabeth E, Hofmann Jonathan N, Rothman Nathaniel, Lan Qing, Berndt Sonja I, Albanes Demetrius, Purdue Mark, Machiela Mitchell J, Chanock Stephen J, Bhatti Parveen, Cozen Wendy, Norman Aaron, Slager Susan L, Cerhan James R, Rajkumar Vincent, Kumar Shaji K, Vachon Celine M, Novak Anne J, Habermann Thomas M, Link Brian K, Salles Gilles, Ghesquieres Herve, Bracci Paige M, Holly Elizabeth, Griffin Rosalie G, Hildebrandt Michelle A T, Vermeulen Roel C H, Kolijn P Martijn, Hjalgrim Henrik, Smedby Karin Ekström, Jayasekara Harindra, Cheah Simon, Monnereau Alain, Chen Yu, Arslan Alan, Zhang Yawei, Camp Nicola J, Sborov Douglas W, Osman Afaf E G, Ziv Elad, De Vivo Immaculata, Joseph Vijai, Teras Lauren R, Patel Alpa V, Kane Eleanor, Vajdic Claire M, Guilloteau Adrien, Cocco Pierluigi, Alemany Laia, Sainz Juan, McKay James, Birmann Brenda M, Casabonne Delphine
Abstract excerpt
Evidence for an association between insulin-like growth factors (IGF) and multiple myeloma (MM) is inconsistent. We examined total IGF-I concentrations and risk of MM by combining baseline serological data among UK Biobank participants (n = 444 187; 732 incident MM) with a two-sample Mendelian randomisation (MR) analysis using identified genetic variants associated with circulating total IGF-I and IGF-binding...
Read the complete abstract on PubMed