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Article

PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosis.

The Journal of biological chemistry - 13 Mar 2009

Pan Wei, da Graca Li S, Shao Yufang, Yin Qian, Wu Hao, Jiang Xuejun

Abstract excerpt

PHAPI/pp32 is a tumor suppressor whose expression is altered in various human cancers. Although PHAPI possesses multiple biochemical activities, the molecular basis for its tumor-suppressive function has remained obscure. Recently we identified PHAPI as an apoptotic enhancer that stimulates apoptosome-mediated caspase activation. In this study, we defined the structural requirement for its activity to stimulate...

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Identifiers

PMID: 19121999
DOI: 10.1074/jbc.M805801200
PMCID: PMC2652289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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