Article
A tumor-specific kinase activity regulates the viral death protein Apoptin.
The Journal of biological chemistry - 27 Dec 2002
Rohn Jennifer L, Zhang Ying-Hui, Aalbers Remco I J M, Otto Norbert, Den Hertog Jeroen, Henriquez Niek V, Van De Velde Cornelis J H, Kuppen Peter J K, Mumberg Dominik, Donner Peter, Noteborn Mathieu H M
Abstract excerpt
Apoptin, a chicken anemia virus-encoded protein, is thought to be activated by a general tumor-specific pathway, because it induces apoptosis in a large number of human tumor or transformed cells but not in their normal, healthy counterparts. Here, we show that Apoptin is phosphorylated robustly both in vitro and in vivo in tumor cells but negligibly in normal cells, and we map the site to threonine 108. A...
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