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Article

Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia.

Biological psychiatry - 15 Jun 2009

Mellios Nikolaos, Huang Hsien-Sung, Baker Stephen P, Galdzicka Marzena, Ginns Edward, Akbarian Schahram

Abstract excerpt

BACKGROUND: Prefrontal deficits in gamma-aminobutyric acid (GABA)ergic gene expression, including neuropeptide Y (NPY), somatostatin (SST), and parvalbumin (PV) messenger RNAs (mRNAs), have been reported for multiple schizophrenia cohorts. Preclinical models suggest that a subset of these GABAergic markers (NPY/SST) is regulated by brain-derived neurotrophic factor (BDNF), which in turn is under the inhibitory...

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Source

Identifiers

PMID: 19121517
DOI: 10.1016/j.biopsych.2008.11.019

Genes

NPY
BDNF
SST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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