Article
MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders.
Schizophrenia research - 1 Dec 2010
Kim Albert H, Reimers Mark, Maher Brion, Williamson Vernell, McMichael Omari, McClay Joseph L, van den Oord Edwin J C G, Riley Brien P, Kendler Kenneth S, Vladimirov Vladimir I
Abstract excerpt
MicroRNAs (miRNAs) are a large family of small non-coding RNAs which negatively control gene expression at both the mRNA and protein levels. The number of miRNAs identified is growing rapidly and approximately one-third is expressed in the brain where they have been shown to affect neuronal differentiation, synaptosomal complex localization and synapse plasticity, all functions thought to be disrupted in...
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