Article
Lack of change in markers of presynaptic terminal abundance alongside subtle reductions in markers of presynaptic terminal plasticity in prefrontal cortex of schizophrenia patients.
Biological psychiatry - 1 Jan 2011
Fung Samantha J, Sivagnanasundaram Sinthuja, Weickert Cynthia Shannon
Abstract excerpt
BACKGROUND: Reduced synaptic connectivity in frontal cortex may contribute to schizophrenia symptoms. While altered messenger RNA (mRNA) and protein expression of various synaptic genes have been found, discrepancies between studies mean a generalizable synaptic pathology has not been identified. METHODS: We determined if mRNAs encoding presynaptic proteins enriched in inhibitory (vesicular gamma-aminobutyric...
Topics
- Adaptor Proteins, Vesicular Transport
- Biomarkers
- Carrier Proteins
- DNA Helicases
- Dysbindin
- Dystrophin-Associated Proteins
- GAP-43 Protein
- Gene Expression
- Humans
- Microtubule-Associated Proteins
- Nerve Growth Factors
- Nerve Tissue Proteins