Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson's disease.

doi:10.1093/brain/aws101

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Article

Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson's disease.

Brain : a journal of neurology - 1 Jun 2012

Costa Cinzia, Sgobio Carmelo, Siliquini Sabrina, Tozzi Alessandro, Tantucci Michela, Ghiglieri Veronica, Di Filippo Massimiliano, Pendolino Valentina, de Iure Antonio, Marti Matteo, Morari Michele, Spillantini Maria Grazia, Latagliata Emanuele Claudio, Pascucci Tiziana, Puglisi-Allegra Stefano, Gardoni Fabrizio, Di Luca Monica, Picconi Barbara, Calabresi Paolo

Abstract excerpt

Although patients with Parkinson's disease show impairments in cognitive performance even at the early stage of the disease, the synaptic mechanisms underlying cognitive impairment in this pathology are unknown. Hippocampal long-term potentiation represents the major experimental model for the synaptic changes underlying learning and memory and is controlled by endogenous dopamine. We found that hippocampal...

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PMID: 22561640
DOI: 10.1093/brain/aws101

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