Article
Single nucleotide polymorphisms in the Trx2/TXNIP and TrxR2 genes of the mitochondrial thioredoxin antioxidant system and the risk of diabetic retinopathy in patients with Type 2 diabetes mellitus.
Journal of diabetes and its complications - 1 Mar 2016
Ramus Sara Mankoc, Cilensek Ines, Petrovic Mojca Globocnik, Soucek Miroslav, Kruzliak Peter, Petrovic Daniel
Abstract excerpt
BACKGROUND: Oxidative stress plays an important role in the pathogenesis of diabetes and its complications. The aim of this study was to examine the possible association between seven single nucleotide polymorphisms (SNPs) of the Trx2/TXNIP and TrxR2 genes encoding proteins involved in the thioredoxin antioxidant defence system and the risk of diabetic retinopthy (DR). DESIGN: Cross-sectional case-control study....
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