Article
Combined glutathione S-transferase T1 and M1 positive genotypes afford protection against type 2 diabetes in Japanese.
Pharmacogenomics - 1 Oct 2007
Hori Masaharu, Oniki Kentaro, Ueda Kentaro, Goto Shuji, Mihara Shuichi, Marubayashi Toru, Nakagawa Kazuko
Abstract excerpt
INTRODUCTION: Diabetes mellitus is associated with an increased production of reactive oxygen species and a reduction in antioxidant defenses. The aim of this study is to determine the association between the incidence of Type 2 diabetes and gene polymorphisms of glutathione S-transferase (GST), which modulates oxidative stress. MATERIALS & METHODS: The associations between the incidence of Type 2 diabetes and...
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