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Article

NOTCH2 is neither rearranged nor mutated in t(1;19) positive oligodendrogliomas.

PloS one - 1 Jan 2009

Benetkiewicz Magdalena, Idbaih Ahmed, Cousin Pierre-Yves, Boisselier Blandine, Marie Yannick, Crinière Emmanuelle, Hoang-Xuan Khê, Delattre Jean-Yves, Sanson Marc, Delattre Olivier

Abstract excerpt

The combined deletion of 1p and 19q chromosomal arms is frequent in oligodendrogliomas (OD) and has recently been shown to be mediated by an unbalanced t(1;19) translocation. Recent studies of 1p/19q co-deleted OD suggest that the NOTCH2 gene is implicated in oligodendrocyte differentiation and m...

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Source

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Identifiers

PMID: 19119320
DOI: 10.1371/journal.pone.0004107
PMCID: PMC2606061

Genes

NOTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19119320-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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NOTCH2 is neither rearranged nor mutated in t(1;19) positive oligodendrogliomas.PMID 19119320Read ↗

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A t(1;19)(q10;p10) Mediates the Combined Deletions of 1p and 19q and Predicts a Better Prognosis of Patients with OligodendrogliomaSemantic proximity Read ↗

Interphase cytogenetics for 1p19q and t(1;19)(q10;p10) may distinguish prognostically relevant subgroups in extraventricular neurocytoma.Semantic proximity Read ↗

Chromosomal imbalances detected by array comparative genomic hybridization in human oligodendrogliomas and mixed oligoastrocytomasSemantic proximity Read ↗

Oligodendroglial Tumors: Refinement of Candidate Regions on Chromosome Arm 1p and Correlation of 1p/19q Status with SurvivalSemantic proximity Read ↗

Utility of targeted next-generation sequencing assay to detect 1p/19q co-deletion in formalin-fixed paraffin-embedded glioma specimens.Semantic proximity Read ↗

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Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing.Semantic proximity Read ↗

Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers.Semantic proximity Read ↗

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FISH-based detection of 1p 19q codeletion in oligodendroglial tumors: procedures and protocols for neuropathological practice – a publication under the auspices of the Research Committee of the European Confederation of Neuropathological Societies (Semantic proximity Read ↗

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