Conformational energy analysis of the substitution of Val for Gly 233 in a functional region of platelet GPIb alpha in platelet-type von Willebrand disease.

Abstract excerpt

Platelet-type von Willebrand disease (PT-vWD) is an autosomal dominant bleeding disorder in which patient platelets exhibit an abnormally increased binding of circulating von Willebrand factor (vWF). We have recently shown that this abnormality is associated with a point mutation resulting in sub...

Topics

• Amino Acid Sequence
• Blood Platelets
• Computer Simulation
• Glycine
• Humans
• Macromolecular Substances
• Models, Molecular
• Molecular Sequence Data
• Mutation
• Peptide Fragments
• Platelet Aggregation