Article
Expression of the phenotypic abnormality of platelet-type von Willebrand disease in a recombinant glycoprotein Ib alpha fragment.
The Journal of clinical investigation - 1 May 1993
Murata M, Russell S R, Ruggeri Z M, Ware J
Abstract excerpt
The platelet GP Ib-IX receptor supports platelet adhesion and activation by binding to vWf in the exposed subendothelial matrix. An abnormal GP Ib-IX complex exists in platelet-type or pseudo-von Willebrand disease and has a characteristic increased affinity for soluble vWf resulting in impaired...
Topics
- Amino Acid Sequence
- Animals
- Blood Platelets
- CHO Cells
- Cricetinae
- Crotalid Venoms
- Genetic Variation
- Glycine
- Hemagglutinins
- Humans
- Kinetics
- Macromolecular Substances
- Phenotype
- Platelet Membrane Glycoproteins
- Recombinant Proteins
- Ristocetin
- Transfection
- Valine