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Macrophages within NSCLC tumour islets are predominantly of a cytotoxic M1 phenotype associated with extended survival

31 Dec 2008

Abstract excerpt

There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. The primary aim of the present study was to determine the immunological phenotype of NSCLC-associated macrophages. CD68(+) macrophages expressing markers of a cytotoxic M1 phenotype or a noncytotoxic M2 phenotype were identified in the islets and stroma of...

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PMID: 19118225
DOI: 10.1183/09031936.00065708

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