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Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype: their possible involvement in pathological processes.

Pathology international - 1 Jan 2010

Ohnishi Koji, Komohara Yoshihiro, Sakashita Naomi, Iyama Ken-Ichi, Murayama Toshihiko, Takeya Motohiro

Abstract excerpt

Although numerous macrophages are found in the lesions of Langerhans cell histiocytosis (LCH), their activation phenotypes and their roles in the disease process have not been clarified. Paraffin-embedded LCH samples were examined on immunohistochemistry and it was found that CD163 can be used to distinguish infiltrated macrophages from neoplastic Langerhans cells (LC). The number of CD163-positve macrophages was...

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PMID: 20055949
DOI: 10.1111/j.1440-1827.2009.02472.x

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STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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