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Article

Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience - 1 Feb 2013

Hartlage-Rübsamen Maike, Waniek Alexander, Roßner Steffen

Abstract excerpt

The amyloid precursor protein (APP) can be proteolytically degraded via non-amyloidogenic α-secretase and amyloidogenic β-secretase pathways. Previously, we have identified the presynaptic protein Munc13-1 as a diacylglycerol/phorbolester (DAG/PE) receptor that contributes to secretory, non-amyloidogenic APP processing after PE stimulation. Here, we used organotypic brain slice cultures from wild-type mice and...

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Source

Identifiers

PMID: 23070049
DOI: 10.1016/j.ijdevneu.2012.10.001

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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