Article
Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle.
Cell metabolism - 3 Nov 2010
Bouskila Michale, Hunter Roger W, Ibrahim Adel F M, Delattre Lucie, Peggie Mark, van Diepen Janna A, Voshol Peter J, Jensen Jørgen, Sakamoto Kei
Abstract excerpt
Glycogen synthase (GS), a key enzyme in glycogen synthesis, is activated by the allosteric stimulator glucose-6-phosphate (G6P) and by dephosphorylation through inactivation of GS kinase-3 with insulin. The relative importance of these two regulatory mechanisms in controlling GS is not established, mainly due to the complex interplay between multiple phosphorylation sites and allosteric effectors. Here we...
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