Article
Genetic evidence for the requirement of RecA loading activity in SOS induction after UV irradiation in Escherichia coli.
Journal of bacteriology - 1 Jul 2006
Ivancic-Bace Ivana, Vlasic Ignacija, Salaj-Smic Erika, Brcic-Kostic Krunoslav
Abstract excerpt
The SOS response in Escherichia coli results in the coordinately induced expression of more than 40 genes which occurs when cells are treated with DNA-damaging agents. This response is dependent on RecA (coprotease), LexA (repressor), and the presence of single-stranded DNA (ssDNA). A prerequisite for SOS induction is the formation of a RecA-ssDNA filament. Depending on the DNA substrate, the RecA-ssDNA filament...
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