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Article

RecJ nuclease is required for SOS induction after introduction of a double-strand break in a RecA loading deficient recB mutant of Escherichia coli.

Biochimie - 1 Sept 2008

Vlasić Ignacija, Ivancić-Baće Ivana, Imesek Mirna, Mihaljević Boris, Brcić-Kostić Krunoslav

Abstract excerpt

The SOS response is an important mechanism which allows Escherichia coli cells to maintain genome integrity. Two key proteins in SOS regulation are LexA (repressor) and RecA (coprotease). The signal for SOS induction is generated at the level of a RecA filament. Depending on the type of DNA damage, a RecA filament is produced by specific activities (helicase, nuclease and RecA loading) of either RecBCD, RecF or a...

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PMID: 18445487
DOI: 10.1016/j.biochi.2008.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RecJ nuclease is required for SOS induction after introduction of a double-strand break in a RecA loading deficient recB mutant of Escherichia coli.PMID 18445487Read ↗

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RecA4142 causes SOS constitutive expression by loading onto reversed replication forks in Escherichia coli K-12.Semantic proximity Read ↗

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RecO and RecR are necessary for RecA loading in response to DNA damage and replication fork stress.Semantic proximity Read ↗

A single mutation, RecB(D1080A,) eliminates RecA protein loading but not Chi recognition by RecBCD enzyme.Semantic proximity Read ↗

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