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Article

Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma.

BMC cancer - 12 Dec 2007

Suzuki Shioto, Heldin Carl-Henrik, Heuchel Rainer Lothar

Abstract excerpt

BACKGROUND: Platelet-derived growth factor (PDGF)-BB and PDGF receptor (PDGFR)-beta are mainly expressed in the developing vasculature, where PDGF-BB is produced by endothelial cells and PDGFR-beta is expressed by mural cells, including pericytes. PDGF-BB is produced by most types of solid tumors, and PDGF receptor signaling participates in various processes, including autocrine stimulation of tumor cell growth,...

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Identifiers

PMID: 18076756
DOI: 10.1186/1471-2407-7-224
PMCID: PMC2234427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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