Article
Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site.
The Journal of general physiology - 1 Jan 2009
Yu Alan S L, Cheng Mary H, Angelow Susanne, Günzel Dorothee, Kanzawa Sanae A, Schneeberger Eveline E, Fromm Michael, Coalson Rob D
Abstract excerpt
Paracellular ion transport in epithelia is mediated by pores formed by members of the claudin family. The degree of selectivity and the molecular mechanism of ion permeation through claudin pores are poorly understood. By expressing a high-conductance claudin isoform, claudin-2, in high-resistance Madin-Darby canine kidney cells under the control of an inducible promoter, we were able to quantitate claudin pore...
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