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Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities

28 Jun 2006

Abstract excerpt

Members of the large claudin family of tight junction (TJ) proteins create the differences in paracellular conductance and charge selectivity observed among different epithelia. Previous studies demonstrated that ionic charge selectivity is influenced by acidic or basic amino acids on the first extracellular domain of claudins. We noted two alternatively spliced variants of claudin-10 in the database, 10a and...

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PMID: 16804102
DOI: 10.1152/ajprenal.00138.2006

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