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Article

Molecular determinants for interfacial binding and conformational change in a soluble diacylglycerol kinase.

The Journal of biological chemistry - 13 Mar 2009

Jerga Agoston, Miller Darcie J, White Stephen W, Rock Charles O

Abstract excerpt

DgkB is a soluble diacylglycerol (DAG) kinase that is essential for membrane lipid homeostasis in many Gram-positive pathogens. Anionic phospholipids, like phosphatidylglycerol (PtdGro), were required for DgkB to recognize diacylglycerol embedded in a phospholipid bilayer. An activity-independent vesicle binding assay was used to determine the role of specific residues in DgkB-PtdGro interactions. Lys15 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19112175
DOI: 10.1074/jbc.M805962200
PMCID: PMC2652325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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