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Structural basis of substrate recognition and membrane association by the bacterial lysyl-phosphatidylglycerol hydrolase AcvB

2025-11-10

Abstract excerpt

Bacteria adapt to environmental stresses via membrane phospholipid remodeling; however, the underlying molecular mechanism remains largely elusive. In Agrobacterium tumefaciens , the lysyl-phosphatidylglycerol (Lys-PG) synthase LpiA and periplasmic hydrolase AcvB genes form an operon that controls Lys-PG levels. We determined the crystal structures of mature AcvB and its C-terminal catalytic domain at 3.1 Å and 1...

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Literature Corpus work
ac1b7c49-4480-5963-90ee-96435514f6ec
DOI
10.1101/2025.11.10.687609
Open publication

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