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Article

Monovalent cation dependence and preference of GHKL ATPases and kinases.

FEBS letters - 5 Jun 2003

Hu Xiaojian, Machius Mischa, Yang Wei

Abstract excerpt

The GHKL phosphotransferase superfamily, characterized by four sequence motifs that form the ATP-binding site, consists of the ATPase domains of type II DNA topoisomerases, Hsp90, and MutL, and bacterial and mitochondrial protein kinases. In addition to a magnesium ion, which is essential for catalysis, a potassium ion bound adjacent to the triphosphate moiety of ATP in a rat mitochondrial protein kinase, BCK...

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PMID: 12782329
DOI: 10.1016/s0014-5793(03)00519-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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