Article
Membrane binding of the insertion sequence of Proteus vulgaris L-amino acid deaminase stabilizes protein structure and increases catalytic activity.
Scientific reports - 20 Oct 2017
Ju Yingchen, Liu Zhihong, Zhang Zizhen, Duan Lijun, Liu Qi, Gu Qiong, Zhang Cheng, Xu Jun, Zhou Huihao
Abstract excerpt
Proteus vulgaris L-amino acid deaminase (pvLAAD) belongs to a class of bacterial membrane-bound LAADs mainly express in genus Proteus, Providencia and Morganella. These LAADs employ a non-cleavable N-terminal twin-arginine translocation (Tat) peptide to transport across membrane and bind to bacterial surface. Recent studies revealed that a hydrophobic insertion sequence (INS) in these LAADs also interacts with...
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