Article
Serial passage of sheep scrapie inoculum in Suffolk sheep.
Veterinary pathology - 1 Jan 2009
Hamir A N, Kunkle R A, Richt J A, Greenlee J J, Miller J M
Abstract excerpt
Scrapie is a naturally occurring fatal neurodegenerative disease of sheep and goats. Susceptibility to the disease is partly dependent upon the genetic makeup of the host. In a recent study, it was shown that sheep intracerebrally inoculated with a US scrapie agent (No. 13-7) developed scrapie and survived for an average of 19 months post inoculation. In the present study, when this scrapie inoculum was further...
Topics
- Animals
- Blotting, Western
- Genetic Predisposition to Disease
- Immunohistochemistry
- Prions
- Scrapie
- Serial Passage
- Sheep
- Survival Analysis