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Article

Phenotypic and molecular evaluation of a chromosome 1q region with linkage and association to type 2 diabetes in humans.

The Journal of clinical endocrinology and metabolism - 1 Apr 2009

Wang Hua, Hays Nicholas P, Das Swapan K, Craig Rebekah L, Chu Winston S, Sharma Neeraj, Elbein Steven C

Abstract excerpt

OBJECTIVE: Linkage to type 2 diabetes (T2D) is well replicated on chromosome 1q21-q23. Within this region, T2D was associated with common single nucleotide polymorphisms that marked an extended linkage disequilibrium block, including the liver pyruvate kinase gene (PKLR), in several European-derived populations. In this study we sought to determine the molecular basis for the association and the phenotypic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19141583
DOI: 10.1210/jc.2008-2132
PMCID: PMC2682467

Genes

PKLR
CLK2
FDPS
HCN3
SCAMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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