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Article

Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes.

BMC medical genetics - 25 Oct 2013

Snogdal Lena Sønder, Grarup Niels, Banasik Karina, Wod Mette, Jørgensen Torben, Witte Daniel R, Lauritzen Torsten, Nielsen Aneta A, Brandslund Ivan, Christensen Cramer, Pedersen Oluf, Yderstræde Knud, Beck-Nielsen Henning, Henriksen Jan Erik, Hansen Torben, Højlund Kurt

Abstract excerpt

BACKGROUND: Type 2 diabetes, obesity and insulin resistance are characterized by hypertriglyceridemia and ectopic accumulation of lipids in liver and skeletal muscle. AGPAT6 encodes a novel glycerol-3 phosphate acyltransferase, GPAT4, which catalyzes the first step in the de novo triglyceride synthesis. AGPAT6-deficient mice show lower weight and resistance to diet- and genetically induced obesity. Here, we...

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Identifiers

PMID: 24156295
DOI: 10.1186/1471-2350-14-113
PMCID: PMC4231429

Genes

GPAT4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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