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Article

Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families.

World journal of gastroenterology - 7 Oct 2007

Yan Shi-Yan, Zhou Xiao-Yan, Du Xiang, Zhang Tai-Ming, Lu Yong-Ming, Cai San-Jun, Xu Xiao-Li, Yu Bao-Hua, Zhou Heng-Hua, Shi Da-Ren

Abstract excerpt

AIM: To investigate the germline mutations of MSH6 gene in probands of Chinese hereditary non-polyposis colorectal cancer (HNPCC) families fulfilling different clinical criteria. METHODS: Germline mutations of MSH6 gene were detected by PCR-based DNA sequencing in 39 unrelated HNPCC probands fulfilling different clinical criteria in which MSH2 and MLH1 mutations were excluded. To further investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17854147
DOI: 10.3748/wjg.v13.i37.5021
PMCID: PMC4434628

Genes

MSH6
MLH1
MSH2

Variants

Provenance

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