Article
How the mother can help: studying maternal Wnt signaling by anti-sense-mediated depletion of maternal mRNAs and the host transfer technique.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2008
Mir Adnan, Heasman Janet
Abstract excerpt
Early development in Xenopus laevis is controlled by maternal gene products synthesized during oogenesis. The dorsal/ventral and anterior/posterior axes are established as a result of canonical Wnt signaling activity. The functions of maternal genes in embryonic development are most effectively studied by introducing anti-sense, oligos complementary to their mRNAs into oocytes and culturing the oocytes long...
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