Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Creating maternal effect mutations in transgenic mice: antisense inhibition of an oocyte gene product.

Developmental biology - 1 Dec 1993

Richards W G, Carroll P M, Kinloch R A, Wassarman P M, Strickland S

Abstract excerpt

Gene products present in mouse oocytes direct development until the two-cell stage and may be important in later development. Here, we demonstrate that expression of a specific maternal protein can be disrupted in mouse oocytes using transgenic antisense RNA technology. An oocyte-specific promoter (mZP3) was utilized to express antisense RNA directed against maternal mRNA encoding tissue-type plasminogen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cells, Cultured
Share to DNA Primers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to Molecular Sequence Data

Share to Mutation

Share to RNA, Messenger

Source

Identifiers

PMID: 8253282
DOI: 10.1006/dbio.1993.1328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Creating maternal effect mutations in transgenic mice: antisense inhibition of an oocyte gene product.PMID 8253282Read ↗

Transgenic RNAi in mouse oocytes: a simple and fast approach to study gene function.Semantic proximity Read ↗

Degradation of maternal mRNA in mouse embryos: Selective degradation of specific mRNAs after fertilizationSemantic proximity Read ↗

An oocyte-specific Cas9-expressing mouse for germline CRISPR/Cas9-mediated genome editing.Semantic proximity Read ↗

Disruption of mouse poly(A) polymerase mGLD-2 does not alter polyadenylation status in oocytes and somatic cellsSemantic proximity Read ↗

The use of antisense oligonucleotides in Xenopus oocytes.Semantic proximity Read ↗

Controlling morpholino experiments: don't stop making antisense.Semantic proximity Read ↗

Targeted gene expression in transgenic Xenopus using the binary Gal4-UAS system.Semantic proximity Read ↗

Expression in in-vivo and in-vitro growing and maturing oocytes: focus on regulation of expression at the translational levelSemantic proximity Read ↗

Depleting gene activities in early Drosophila embryos with the "maternal-Gal4-shRNA" system.Semantic proximity Read ↗

Compensation for a gene trap mutation in the murine microtubule-associated protein 4 locus by alternative polyadenylation and alternative splicing.Semantic proximity Read ↗

Extraembryonic expression of the human MHC class I gene HLA-G in transgenic mice. Evidence for a positive regulatory region located 1 kilobase 5' to the start site of transcription.Semantic proximity Read ↗

How the mother can help: studying maternal Wnt signaling by anti-sense-mediated depletion of maternal mRNAs and the host transfer technique.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.