Article
Creating maternal effect mutations in transgenic mice: antisense inhibition of an oocyte gene product.
Developmental biology - 1 Dec 1993
Richards W G, Carroll P M, Kinloch R A, Wassarman P M, Strickland S
Abstract excerpt
Gene products present in mouse oocytes direct development until the two-cell stage and may be important in later development. Here, we demonstrate that expression of a specific maternal protein can be disrupted in mouse oocytes using transgenic antisense RNA technology. An oocyte-specific promote...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- DNA Primers
- Gene Expression
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Oocytes
- Poly A
- Promoter Regions, Genetic
- Protein Synthesis Inhibitors
- RNA, Antisense
- RNA, Messenger
- Tissue Plasminogen Activator