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Safety and Immunogenicity of Adenovirus-Vectored Near-Consensus HIV Type 1 Clade B <i>gag</i> Vaccines in Healthy Adults

24 Dec 2008

Abstract excerpt

Vaccines inducing pathogen-specific cell-mediated immunity are being developed using attenuated adenoviral (Ad) vectors. We report the results of two independent Phase I trials of similar replication-deficient Ad5 vaccines containing a near-consensus HIV-1 clade B gag transgene. Healthy HIV-uninfected adults were enrolled in two separate, multicenter, dose-escalating, blinded, placebo-controlled studies to assess...

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PMID: 19108693
DOI: 10.1089/aid.2008.0212

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