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Article

A Simian Replication-Defective Adenoviral Recombinant Vaccine to HIV-1 Gag

1 Feb 2003

Abstract excerpt

In animal models, E1-deleted human adenoviral recombinants of the serotype 5 (AdHu5) have shown high efficacy as vaccine carriers for different Ags including those of HIV-1. Humans are infected by common serotypes of human adenovirus such as AdHu5 early in life and a significant percentage has high levels of neutralizing Abs to these serotypes, which will very likely impair the efficacy of recombinant vaccines...

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PMID: 12538702
DOI: 10.4049/jimmunol.170.3.1416

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