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Article

A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma.

Nature reviews. Endocrinology - 1 Apr 2016

Romei Cristina, Ciampi Raffaele, Elisei Rossella

Abstract excerpt

The rearranged during transfection (RET) proto-oncogene was identified in 1985 and, very soon thereafter, a rearrangement named RET/PTC was discovered in papillary thyroid carcinoma (PTC). After this discovery, other RET rearrangements were found in PTCs, particularly in those induced by radiation. For many years, it was thought that these genetic alterations only occurred in PTC, but, in the past couple of...

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Share to Adenocarcinoma, Follicular
Share to Carcinoma, Medullary
Share to Carcinoma, Neuroendocrine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Papillary

Share to Multiple Endocrine Neoplasia Type 2a

Share to Proto-Oncogene Proteins c-ret

Share to Thyroid Cancer, Papillary

Share to Thyroid Carcinoma, Anaplastic

Source

Identifiers

PMID: 26868437
DOI: 10.1038/nrendo.2016.11

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma.PMID 26868437Read ↗

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PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomasSemantic proximity Read ↗

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Central role of RET in thyroid cancer.Semantic proximity Read ↗

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