Article
The HIF-1alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers.
Cancer biology & therapy - 1 Jan 2009
Foley Ruth, Marignol Laure, Thomas Arun Z, Cullen Ivor M, Perry Antoinette S, Tewari Prerna, O'Grady Anthony, Kay Elaine, Dunne Barbara, Loftus Barbara, Watson William R, Fitzpatrick John M, Woodson Karen, Lehman Terri, Hollywood Donal, Lynch Thomas H, Lawler Mark
Abstract excerpt
We investigated the role of the C1772T polymorphisms in exon 12 of the Hypoxia-inducible factor-1 alpha (HIF-1alpha) gene C1772T genotype in prostate cancer (PCa) and amplification of the hypoxic response. We identified the heterozygous germline CT genotype as an increased risk factor for clinically localised prostate cancer (Odds ratio = 6.2; p < 0.0001). While immunostaining intensity for HIF-1alpha and VEGF...
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