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Article

The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration.

European journal of cancer (Oxford, England : 1990) - 1 Jan 2014

Fraga Avelino, Ribeiro Ricardo, Príncipe Paulo, Lobato Carlos, Pina Francisco, Maurício Joaquina, Monteiro Cátia, Sousa Hugo, Calais da Silva F, Lopes Carlos, Medeiros Rui

Abstract excerpt

The hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. In this study we sought to evaluate the association of a functional genetic polymorphism in HIF1A wi...

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Identifiers

PMID: 24090974
DOI: 10.1016/j.ejca.2013.09.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-24090974-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration.PMID 24090974Read ↗

Genetic polymorphisms in HIF1A are associated with prostate cancer risk in a Chinese population.Semantic proximity Read ↗

The HIF-1alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers.Semantic proximity Read ↗

The homozygous P582S mutation in the oxygen-dependent degradation domain of HIF-1 alpha is associated with increased risk for prostate cancer.Semantic proximity Read ↗

HIF1A C1772T polymorphism leads to HIF-1α mRNA overexpression in prostate cancer patients.Semantic proximity Read ↗

Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to androgen-independent prostate cancer.Semantic proximity Read ↗

Hypoxia-inducible factor-1alpha gene polymorphisms and cancer risk: a meta-analysis.Semantic proximity Read ↗

Connecting Gene Variation to Treatment Outcomes in Metastatic Castration-Resistant Prostate Adenocarcinoma: Insights into Second-Generation Androgen Receptor Axis-Targeted Therapies.Semantic proximity Read ↗

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Genetic effects of vascular endothelial growth factor A (VEGF-A) gene mutations and their association with poor clinical characteristics of prostate cancer.Semantic proximity Read ↗

CYP17A1 polymorphism c.-362T>C predicts clinical outcome in metastatic castration-resistance prostate cancer patients treated with abiraterone.Semantic proximity Read ↗

Hypoxia-inducible factor-1α C1772T polymorphism and cancer risk: a meta-analysis including 18,334 subjects.Semantic proximity Read ↗

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