Article
Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer.
BMC urology - 31 Jan 2017
Fraga Avelino, Ribeiro Ricardo, Coelho André, Vizcaíno José Ramon, Coutinho Helena, Lopes José Manuel, Príncipe Paulo, Lobato Carlos, Lopes Carlos, Medeiros Rui
Abstract excerpt
BACKGROUND: In this study we sought if, in their quest to handle hypoxia, prostate tumors express target hypoxia-associated molecules and their correlation with putative functional genetic polymorphisms. METHODS: Representative areas of prostate carcinoma (n = 51) and of nodular prostate hyperplasia (n = 20) were analysed for hypoxia-inducible factor 1 alpha (HIF-1α), carbonic anhydrase IX (CAIX), lysyl oxidase...
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