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Article

HIF1A C1772T polymorphism leads to HIF-1α mRNA overexpression in prostate cancer patients.

Cancer biology & therapy - 1 Jul 2012

Vainrib Michael, Golan Maya, Amir Sharon, Dang Duyen T, Dang Long H, Bar-Shira Anat, Orr-Urtreger Avi, Matzkin Haim, Mabjeesh Nicola J

Abstract excerpt

Hypoxia-inducible factor 1α (HIF-1α) gene polymorphisms have been investigated for a possible role in mediating genetic predisposition to cancer. Our previous data show that men homozygous to C1772T polymorphism had 4-fold risk to develop prostate cancer. Therefore, we studied the effects of C1772T polymorphism on HIF-1α expression. HIF-1α mRNA expression levels were significantly higher in peripheral blood...

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PMID: 22647679
DOI: 10.4161/cbt.20554

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