Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The atypical CDK activator Spy1 regulates the intrinsic DNA damage response and is dependent upon p53 to inhibit apoptosis.

Cell cycle (Georgetown, Tex.) - 1 Jan 2009

McAndrew Christopher W, Gastwirt Randy F, Donoghue Daniel J

Abstract excerpt

The intrinsic damage response is activated by DNA damage that arises during the cell division process. The ability of the cell to repair this damage during proliferation is important for normal cell growth and, when disrupted, may lead to increased mutagenesis and tumorigenesis. The atypical CDK activator, Spy1, was previously shown to promote cell survival, prevent apoptosis and inhibit checkpoint activation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Comet Assay
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinases

Share to Cyclin E

Share to DNA Damage

Share to Pyrimidine Dimers

Share to RNA, Small Interfering

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 19106603
DOI: 10.4161/cc.8.1.7451
PMCID: PMC2782695

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The atypical CDK activator Spy1 regulates the intrinsic DNA damage response and is dependent upon p53 to inhibit apoptosis.PMID 19106603Read ↗

Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation.Semantic proximity Read ↗

The Atypical Cyclin-Like Protein Spy1 Overrides p53-Mediated Tumour Suppression and Promotes Susceptibility to Breast TumorigenesisSemantic proximity Read ↗

The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancerSemantic proximity Read ↗

Spy1 Interacts with p27Kip1 to Allow G1/S ProgressionSemantic proximity Read ↗

Human SpeedySemantic proximity Read ↗

Spy1, a unique cell cycle regulator, alters viability in ALS motor neurons and cell lines in response to mutant SOD1-induced DNA damageSemantic proximity Read ↗

DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro.Semantic proximity Read ↗

p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775Semantic proximity Read ↗

p53 is a NF-Y- and p21-independent, Sp1-dependent repressor of cyclin B1 transcription.Semantic proximity Read ↗

Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells.Semantic proximity Read ↗

Expression of Spy1 protein in human Non-Hodgkin’s Lymphomas is correlated with phosphorylation of p27Kip1 on Thr187 and cell proliferationSemantic proximity Read ↗

The Cyclin-dependent Kinase Inhibitor p16INK4a Physically Interacts with Transcription Factor Sp1 and Cyclin-dependent Kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p Spontaneously and in Response to Ultraviolet Light-induced DNA DamageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.