Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Speedy

29 Apr 2002

Abstract excerpt

The decision for a cell to self-replicate requires passage from G1 to S phase of the cell cycle and initiation of another round of DNA replication. This commitment is a critical one that is tightly regulated by many parallel pathways. Significantly, these pathways converge to result in activation of the cyclin-dependent kinase, cdk2. It is, therefore, important to understand all the mechanisms regulating cdk2 to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Microtubule and mitosis dynamics

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 11980914
DOI: 10.1083/jcb.200109045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human SpeedyPMID 11980914Read ↗

Spy1 Interacts with p27Kip1 to Allow G1/S ProgressionSemantic proximity Read ↗

The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancerSemantic proximity Read ↗

Extensive Expansion of the <i>Speedy</i> gene Family in Homininae and Functional Differentiation in HumansSemantic proximity Read ↗

Targeting cyclin-dependent kinase 2 (CDK2) interactions with cyclins and Speedy 1 (Spy1) for cancer and male contraceptionSemantic proximity Read ↗

Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation.Semantic proximity Read ↗

SPIN1 is a proto-oncogene and SPIN3 is a tumor suppressor in human seminomaSemantic proximity Read ↗

The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expressionSemantic proximity Read ↗

RGS12 as a Novel Maternal-Effect Gene Causes Arrest at the Pronuclear Stage of Human ZygoteSemantic proximity Read ↗

Assembly of a Parts List of the Human Mitotic Cell Cycle MachinerySemantic proximity Read ↗

Review of rationale and progress toward targeting cyclin-dependent kinase 2 (CDK2) for male contraception†Semantic proximity Read ↗

The Atypical Cyclin-Like Protein Spy1 Overrides p53-Mediated Tumour Suppression and Promotes Susceptibility to Breast TumorigenesisSemantic proximity Read ↗

Loss of chromosome Y in primary tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.