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Article

Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation.

The Journal of biological chemistry - 17 Nov 2006

Gastwirt Randy F, Slavin Daniela A, McAndrew Christopher W, Donoghue Daniel J

Abstract excerpt

Spy1 is the originally identified member of the Speedy/Ringo family of vertebrate cell cycle regulators, which can control cell proliferation and survival through the atypical activation of cyclin-dependent kinases. Here we report a role for Spy1 in apoptosis and checkpoint activation in response to UV irradiation. Using an inducible system allowing for regulated expression of Spy1, we show that Spy1 expression...

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Source

Identifiers

PMID: 16951407
DOI: 10.1074/jbc.M604720200

Genes

CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation.PMID 16951407Read ↗

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