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Article

The Drosophila cell adhesion molecule klingon is required for long-term memory formation and is regulated by Notch.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2009

Matsuno Motomi, Horiuchi Junjiro, Tully Tim, Saitoe Minoru

Abstract excerpt

The ruslan (rus) mutant was previously identified in a behavioral screen for mutants defective in long-lasting memory, which consists of two consolidated memory types, anesthesia-resistant memory, and protein synthesis-dependent long-term memory (LTM). We demonstrate here that rus is a new allele of klingon (klg), which encodes a homophilic cell adhesion molecule. Klg is acutely required for LTM but not...

Topics

Anesthesia
Animals
Cell Adhesion Molecules
Drosophila
Drosophila Proteins
Eye Proteins
Gene Expression Regulation
Memory
Mutation
Receptors, Notch
Signal Transduction

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PMID: 19104051
DOI: 10.1073/pnas.0807665106
PMCID: PMC2606903

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