Article
The AKAP Yu is required for olfactory long-term memory formation in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2007
Lu Yubing, Lu Yi-Sheng, Shuai Yichun, Feng Chunhua, Tully Tim, Xie Zuoping, Zhong Yi, Zhou Hai-Meng
Abstract excerpt
Extensive neurogenetic analysis has shown that memory formation depends critically on cAMP-protein kinase A (PKA) signaling. Details of how this pathway is involved in memory formation, however, remain to be fully elucidated. From a large-scale behavioral screen in Drosophila, we identified the yu mutant to be defective in one-day memory after spaced training. The yu mutation disrupts a gene encoding an A-kinase...
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