Article
The molecular chaperone Hsp90 is a component of the cap-binding complex and interacts with the translational repressor Cup during Drosophila oogenesis.
Gene - 1 Mar 2009
Pisa Viviana, Cozzolino Marianna, Gargiulo Serena, Ottone Cristina, Piccioni Federica, Monti Maria, Gigliotti Silvia, Talamo Fabio, Graziani Franco, Pucci Piero, Verrotti Arturo C
Abstract excerpt
In metazoa, the spatio-temporal translation of diverse mRNAs is essential to guarantee proper oocyte maturation and early embryogenesis. The eukaryotic translation initiation factor 4E (eIF4E), which binds the 5' cap structure of eukaryotic mRNAs, associates with either stimulatory or inhibitory factors to modulate protein synthesis. In order to identify novel factors that might act at the translational level...
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