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Mouse zygote-specific proteasome assembly chaperone important for maternal-to-zygotic transition

23 Nov 2012

Abstract excerpt

During the maternal-to-zygotic transition (MZT), maternal proteins in oocytes are degraded by the ubiquitin-proteasome system (UPS), and new proteins are synthesized from the zygotic genome. However, the specific mechanisms underlying the UPS at the MZT are not well understood. We identified a molecule named zygote-specific proteasome assembly chaperone (ZPAC) that is specifically expressed in mouse gonads, and...

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PMID: 23429752
DOI: 10.1242/bio.20123020

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