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Article

Analysis of a Jup hypomorphic allele reveals a critical threshold for postnatal viability.

Genesis (New York, N.Y. : 2000) - 1 Oct 2012

Swope David, Li Jifen, Muller Eliane J, Radice Glenn L

Abstract excerpt

Mutations in the human Jup gene cause arrhythmogenic right ventricular cardiomyopathy (ARVC), a heart muscle disease that often leads to sudden cardiac death. Inactivation of the murine Jup gene (also known as plakoglobin) results in embryonic lethality due to cardiac rupture. In an effort to generate a conditional knockout allele, a neomycin cassette was introduced into the murine plakoglobin (PG) gene. This...

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Identifiers

PMID: 22522917
DOI: 10.1002/dvg.22034
PMCID: PMC3410040

Genes

CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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