Article
The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
Nature communications - 28 Apr 2020
Zhang Jingjing, Gurusaran Manickam, Fujiwara Yasuhiro, Zhang Kexin, Echbarthi Meriem, Vorontsov Egor, Guo Rui, Pendlebury Devon F, Alam Intekhab, Livera Gabriel, Emmanuelle Martini, Wang P Jeremy, Nandakumar Jayakrishnan, Davies Owen R, Shibuya Hiroki
Abstract excerpt
Breast cancer susceptibility gene II (BRCA2) is central in homologous recombination (HR). In meiosis, BRCA2 binds to MEILB2 to localize to DNA double-strand breaks (DSBs). Here, we identify BRCA2 and MEILB2-associating protein 1 (BRME1), which functions as a stabilizer of MEILB2 by binding to an α-helical N-terminus of MEILB2 and preventing MEILB2 self-association. BRCA2 binds to the C-terminus of MEILB2,...
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