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Article

The impact of folate pathway polymorphisms combined to nutritional deficiency as a maternal predisposition factor for Down syndrome.

Disease markers - 1 Jan 2008

Santos-Rebouças C B, Corrêa J C, Bonomo A, Fintelman-Rodrigues N, Moura K C V, Rodrigues C S C, Santos J M, Pimentel M M G

Abstract excerpt

Polymorphisms in genes encoding folate metabolizing enzymes have been linked to an increased risk of maternal chromosomal nondisjunction in several populations. With the purpose of evaluating this relationship, we compared the frequencies of 677C>T and 1298A>C polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and 66A>G in the methionine synthase reductase gene (MTRR) between 103 young mothers...

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Source

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Identifiers

PMID: 19096127
DOI: 10.1155/2008/487023
PMCID: PMC3827818

Genes

MTHFR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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